Bartonella henselaetrimeric autotransporter adhesin BadA expression interferes with effector translocation by the VirB/D4 type IV secretion system
نویسندگان
چکیده
منابع مشابه
Structure of the Head of the Bartonella Adhesin BadA
Trimeric autotransporter adhesins (TAAs) are a major class of proteins by which pathogenic proteobacteria adhere to their hosts. Prominent examples include Yersinia YadA, Haemophilus Hia and Hsf, Moraxella UspA1 and A2, and Neisseria NadA. TAAs also occur in symbiotic and environmental species and presumably represent a general solution to the problem of adhesion in proteobacteria. The general ...
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recent publication, Akopyan et al. (2011) provide evidence challenging this canonical “one-step” model for the transport of effector proteins, proposing that in Yersinia pseudotuberculosis at least, a “two-step” model of T3SS-dependent protein translocation may be possible. In this “two-step” process, bacterial effectors are first secreted to the surface of the bacterium and then translocated a...
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Many Gram-negative pathogens possess virulence-related type III secretion systems. Salmonella enterica uses two of these systems, encoded on the pathogenicity islands SPI-1 and SPI-2, respectively, to translocate more than 30 effector proteins into eukaryotic host cells. SteA is one of the few effectors that can be translocated by both systems. We investigated the conditions affecting the synth...
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Type IV secretion systems (T4SS) can mediate the translocation of bacterial virulence proteins into host cells. The plant pathogen Agrobacterium tumefaciens uses a T4SS to deliver a VirD2-single stranded DNA complex as well as the virulence proteins VirD5, VirE2, VirE3, and VirF into host cells so that these become genetically transformed. Besides plant cells, yeast and fungi can efficiently be...
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ژورنال
عنوان ژورنال: Cellular Microbiology
سال: 2012
ISSN: 1462-5814
DOI: 10.1111/cmi.12070